Both Femara and clomiphene may be prescribed to treat female* infertility. This allows them to monitor how strong your bones are. This medicine is available only with your doctor's prescription. The most common cause of ovulation problems that result in infertility is polycystic ovary syndrome (PCOS). But Femara is also sometimes used to treat infertility that doesnt have an obvious cause. You should take Femara according to your doctors or another healthcare professionals instructions. Most people are given letrozole for 5 years, but some will take it for up to 10 years. Serious side effects of Femara that have been reported include: Learn more about some of the side effects Femara may cause. Although theyre not common side effects, in some cases, Femara can cause anxiety or depression. (Letrozole is the active drug in Femara.) So, dont be afraid to ask questions or offer feedback on your treatment. And dont stop taking Femara unless your doctor recommends it. These include: Youre more likely to have success with Femara treatment for infertility if your body isnt already ovulating. This condition can become very painful and may lead to infertility in some people. When will I ovulate after taking letrozole? I was prescribed Letrozole about 6 weeks before my operation, bilateral mastectomy with implants. It is usually used when you have been through a natural menopause. PCOS is a condition that causes hormone problems, irregular or skipped periods, and cysts on your ovaries. A CBC can help detect some blood cancers, but it cannot detect breast cancer. Visit Medicine Assistance Tool to find programs that may help lower your cost of Femara. What can I do to help prevent the aches and pains that Ive heard are a side effect of taking Femara? If you have osteoporosis or risk factors* for developing this condition, talk with your doctor before starting Femara. Limiting alcohol, caffeine, and spicy foods. Trying mental and stress-relief activities such as. These lists do not include all possible side effects. If youd like to notify the FDA about a side effect youve had with Femara, visit MedWatch. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Most doctors wont prescribe Femara for more than six cycles of treatment. Before taking Femara, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. However, its important to note that alcohol and Femara can have similar side effects. G n' J FormerMember over 6 years ago in reply to Dreamthief For information on how Femara performed in clinical studies, see the drugs prescribing information. Some research from 2011 showed that Femara can help manage pain related to endometriosis. Taking more than the recommended dosage of Femara may result in overdose in some people. If youre concerned about weight gain while taking Femara, talk with your doctor. And you should continue to avoid breastfeeding for at least 3 weeks after your last dose of the drug. Before you take Femara, tell your doctor if you have any liver problems, including cirrhosis. Femara isnt currently approved to treat infertility in females. Cancer cells multiply quickly, but some healthy cells in your body also multiply quickly. The half-life of Femara is about 2 days. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. It should be safe to drink alcohol during your Femara treatment. For this use, youll usually take the drug for 5 years following surgery to remove the cancer. PCOS is a condition that causes hormone problems, irregular or skipped periods, and cysts on your ovaries. Off-label drug use is when a drug thats approved for one use is used for a different one thats not approved. You might take a look at the Calling Long Term Survivors thread, I believe there's a couple of women who have been on it for 4+ years. Femara may cause mild side effects other than the ones listed above. But some people may experience side effects while taking this drug. However, if you think youre having a medical emergency, you should call 911 or your local emergency number. What should I know about Femara vs. Arimidex? Femara is also used off-label to treat infertility. Use of the term female in this article refers to sex assigned at birth. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. Its a hormone therapy for breast cancer. Use of the term female in this article refers to sex assigned at birth. If you have serious side effects from Femara, call your doctor right away. How does Arimidex work? If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. In fact, aromatase inhibitors such as Femara are recommended in current guidelines for people with HR+ breast cancer. Some people start taking letrozole after a few years of taking the hormone therapy drug tamoxifen . Clomid has been discontinued, but generic versions of clomiphene are still available. Serious side effects from Femara can occur, but they arent common. The greater the density, the stronger your bones are. Femara comes as tablets that are taken by mouth. But its not known how often this occurs in people using Femara. If your doctor confirms that you had a mild allergic reaction to Femara, theyll decide if you should continue taking it. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Femara, which works by lowering your estrogen level, is prescribed for females* whove gone through menopause. Talk with your doctor if you have bothersome spotting while taking Femara. You may have questions about Femara and your treatment plan. Female hormones that occur naturally in the body can increase the growth of some breast cancers. You should take Letrozole at about the same time each day. Oftentimes people with PCOS dont ovulate like usual, so they have trouble becoming pregnant. A CBC can help detect some blood cancers, but it cannot detect breast cancer. A study has found that taking Femara for 10 years instead of 5: reduces the risk of recurrence. Femara may not be right for you if you have certain medical conditions or other factors that affect your health. And generics tend to cost less than brand-name drugs. After youve gone through menopause, your ovaries no longer produce estrogen. Off-label use is when a drug thats approved to treat one condition is used to treat another condition. Letrozole can stop or slow the growth of these cancers. . Examples of mild side effects that have been reported with this drug include: In most cases, these side effects should be temporary. You may take Letrozole with or without food. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. If you have more questions about how Femara and clomiphene are alike and different, talk with your doctor. Withdrawal symptoms are side effects that can happen when you stop taking a drug that your body has become dependent on. Generic forms of Femara are available. Swelling from Femara usually occurs in your arms, feet, hands, or legs. Spotting may occur along with other side effects from Femara, such as belly pain or cramping. And you shouldnt become pregnant or breastfeed for at least 3 weeks after your last dose of the drug. Femara is prescribed to treat certain types of breast cancer in adult females* who have gone through menopause. These cancers can be treated with hormone therapies that work by lowering estrogen levels in your body. As with all medications, the cost of Femara can vary. Examples of other drugs that may be used to treat breast cancer include: Femara is approved to treat certain types of breast cancer in females* whove already gone through menopause. Swelling, another common side effect of Femara, can cause you to gain weight as your body holds on to water. I had no radiotherapy or chemotherapy. When used for this purpose, Femara helps lower the risk of your cancer coming back. Femara is FDA-approved to treat only certain types of breast cancer. * Its mainly used when infertility is caused by problems with ovulation (the release of eggs from your ovaries). Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Femara. Your insurance plan may require you to get prior authorization before approving coverage for Femara. If you think you could be pregnant or have pregnancy symptoms, tell your doctor before you start taking Femara. Femara may cause fatigue (lack of energy) in some people. To help make sure that you dont miss a dose, try setting a reminder on your phone. Below are commonly used dosages, but always take the dosage your doctor prescribes. The list below includes factors to consider. Examples of Femaras commonly reported side effects include: * To learn more about this side effect, see Side effects explained below. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Clomid was a brand-name drug thats no longer available. It can also interact with certain supplements as well as certain foods. These lists dont include all possible side effects. Blood tests may be needed to check for unwanted effects. Prophylactic mastectomy is surgery to remove breast tissue. So, chemotherapy can affect both healthy cells and cancer cells. Whether Femara or clomiphene is more effective for you may depend on the cause of your infertility. Femara and clomiphene are both used to induce (cause) ovulation in females* who are having trouble becoming pregnant. Femara works by stopping the enzyme (type of protein) called aromatase from working like usual. However, be sure to take the dosage your doctor prescribes for you. The usual dosage of Femara for inducing ovulation is 2.5 mg taken by mouth once daily for 5 days. * An allergic reaction is possible after taking Femara. Also describe any vitamins, herbs, or supplements you use. This date is typically 1 year from the date they dispensed the medication. Find answers to some commonly asked questions about Femara. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. The drugs work by lowering estrogen levels in your body, which helps stop breast cancer from growing. However, statistics show that many people with breast cancer have an excellent chance of. And they want you to get the best care possible. You shouldnt take Femara unless its been prescribed by a healthcare professional. After menopause, your body produces less estrogen, which can weaken your bones. Femara is a brand-name prescription drug thats approved to treat breast cancer in females* whove gone through menopause. Some that are rare (occurring in less than 10% of patients) are not listed here. With early breast cancer, the cancer hasnt spread out of either your breast or the lymph nodes in your armpit. And the drug doesnt need to be stopped gradually to prevent side effects from occurring. For this purpose, Femara is used after treatment with another breast cancer drug that blocks. Common side effects can be like menopause symptomsand include hot flushes, difficulty sleeping, tiredness and low mood. Treatment will be taken over five consecutive days. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. breast and liver cancer in 2010. chemo and radio. If youd like to know more about treatment options for infertility, talk with your doctor. Other drugs are available that can treat breast cancer. Read on to learn how to take Femara, what its uses and side effects are, and more. But try to always stick to the same time each day. This stops estrogen from being able to stimulate breast cancer cells to grow and multiply. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. However, if you find that Femara gives you a headache, or makes you feel dizzy, nauseous, or tired, drinking alcohol may worsen these side effects. Not all side effects are listed above. . No, you likely wont. But if they become more severe or dont go away, talk with your doctor or pharmacist. If you have questions about the risks of Femara use in pregnancy, talk with your doctor. If you have questions or concerns about changes in your weight, talk with your doctor or pharmacist. This condition is called controlled ovarian hyperstimulation, or superovulation. If you miss a dose of Femara, take it as soon as you remember, unless its almost time for your next dose. They can recommend some ways to manage this side effect. Learn how CBCs are used in the treatment of breast cancer. reduces the risk of a new breast cancer . How to Use Letrozole for Fertility Femara (letrozole) is offered in 2.5-milligram yellow, film-coated tablets. Femara is FDA-approved to treat advanced breast cancer thats hormone receptor-positive (HR+). Can breast cancer return while on letrozole? Femara is also sometimes used off-label to treat infertility in females with endometriosis. Ophthalmology 54 years experience Few: Femara ( letrozole) blocks the formation of estrogen. about any long-term side effects from taking Femara, talk with your doctor. Allergic reaction. Breast cancer cells may form a tumor in the breast and spread to other areas of the body. Like other drugs, Femara can cause mild or serious side effects. Infertility is often caused by problems with ovulation (when eggs are released from your ovaries). If youre not having periods when starting Femara, your doctor will recommend when you should start taking the drug. Its a prescription drug thats used to treat certain types of breast cancer in adult females* who have gone through menopause. 2005-2023 Healthline Media a Red Ventures Company. Its possible that you may continue to have side effects from Femara even after you stop taking it. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Chemotherapy describes traditional drugs used to treat cancer. Costs of prescription drugs can vary depending on many factors. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Letrozole Information for Healthcare Professionals, Letrozole Updated 11/2020. Ask your doctor what other medications are better options for you. For more information about using Femara for infertility, see the section Off-label use of Femara for infertility above. What Types of Breast Cancer Have the Highest Recurrence Rates? Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. But if you have liver problems, your doctor may recommend that you take the drug once every other day. But make sure you talk with your doctor or pharmacist before taking any new medications with Femara. Stopping Femara treatment isnt known to cause side effects. Another 2019 review of studies found Femara and clomiphene to be similarly effective in treating unexplained infertility. Side effects usually improve after a few months as your body gets used to the medicine. Learn more about some of the side effects that Femara may cause. It may also be used when someone is premenopausal and having treatment to stop the ovaries working (temporary menopause). Serious side effects from Femara arent common, but they can occur. Can diet help improve depression symptoms? These include: The following information describes dosages that are commonly used or recommended. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. Healthline Media does not provide medical advice, diagnosis, or treatment. This is especially helpful when you first start taking new drugs or using a combination of treatments. Examples of both mild and serious side effects that can occur when using Femara for infertility include: Youll usually take Femara by mouth once daily for 5 days after the start of your menstrual cycle. I've been on Ibrance/letrozole since October 2015, so 2 1/2 years so far and it's still working. Femara can stay in your system for several weeks after your last dose. Femara contains the drug letrozole. Femara is a kind of drug called an aromatase inhibitor. For this purpose, tamoxifen must have been used for at least 5 years. Femara can interact with several types of drugs. At that point, the aromatase enzyme is the main pathway that your body uses to make estrogen. And because Femara also lowers your estrogen level, the drug can add to this effect. Femara is a hormone therapy thats used for HR+ breast cancer. For more information about Femara, including details about the types of breast cancer it treats, see this in-depth article on the drug. The insurance company will review the request and let you and your doctor know if your plan will cover Femara. Risks of extended treatment to consider may include weakening of your bones or raised cholesterol levels. If youre pregnant or thinking about becoming pregnant, talk with your doctor. If you have questions or concerns about this potential side effect, talk with your doctor or pharmacist. Medically reviewed by Carmen Fookes, BPharm. (With dependence, your body needs the drug in order to function like usual.) Dont take two doses together to make up for a missed dose. This is because the drug can stay in your system for about 7 days after you stop the treatment. If you have questions about whether its safe for you to drive or operate machinery during your treatment, talk with your doctor or pharmacist. If you have questions or concerns about using Femara for infertility, talk with your doctor. Femara tablets should be stored at room temperature (77F/25C) in a tightly sealed container. Femara comes as tablets that you take by mouth. High cholesterol. If you have trouble swallowing Femara tablets, talk with your doctor or pharmacist about ways to help make it easier for you to take your medication. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. The expiration date helps guarantee that the medication is effective during this time. The American Society of Clinical Oncology (ASCO) recommends that 10 years should be the maximum duration of therapy, based on their 2019 clinical practice guideline update. When estrogen is blocked, the pituitary gland gets a message that it needs to produce follicle-stimulating hormone (FSH), which stimulates the ovary to produce an egg. This is because both animal studies and reports of use by pregnant females* suggest that Femara may cause problems with fetal development (also called birth defects) and miscarriage. Am I at a higher risk for certain side effects from Femara? This means that Femara will no longer be in your body when you ovulate or conceive. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. Its available in one strength: 2.5 mg. For information on the effectiveness of Femara, see the Femara uses section below. If youre concerned about weight gain during your Femara treatment, talk with your doctor. All rights reserved. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Prophylactic mastectomy is surgery to remove breast tissue. So, side effects that you have while taking Femara may continue for a few weeks after you stop using it. When you stop taking letrozole, most persistent side effects should improve within a week or 10 days, and as long as you have taken it for at least 5 years, then letrozole should continue to reduce the risk of breast cancer coming back for many years after you stop taking it. Your doctor will determine the best dosage to fit your needs. Tell them about all prescription, over-the-counter, and other drugs you take. Headaches were a common side effect in studies of Femara. Femara is a hormone therapy thats approved to treat certain forms of breast cancer in females* whove gone through menopause. Learn more. Femara has been found effective for treating certain types of breast cancer. If letrozole stops working and your breast cancer comes back, your specialist may prescribe another hormone drug. But sometimes Femara is used off-label for other conditions. why should I stop; would I benefit from stopping; would I benefit from continuing, who would monitor me, etc. Such drinks and foods may worsen hot flashes. Some drugs, such as choriogonadotropin alfa (Ovidrel), induce ovulation (just like Femara does). Liver problems. See Femaras prescribing information for details. When is the best time of day to take letrozole? However, its possible that certain plant-based estrogens (called phytoestrogens) could make Femara less effective. In addition to the uses listed above, Femara may be used off-label. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Because of this, you shouldnt breastfeed while youre taking Femara. If you drink alcohol and youre concerned about how this might affect your condition, talk with your doctor. This enzyme is the main way that your body makes estrogen after youve gone through menopause. To find out how often this side effect occurred in clinical studies, see the drugs prescribing information. This dosage is 1 tablet once daily. But try to take it around the same time on each of the 5 days that youre taking the drug. Femara is used in the following ways for early HR+ breast cancer: Femara is used in the following ways for advanced breast cancer thats either HR+ or whose hormone receptor status isnt known: * Sex and gender exist on spectrums. These breast cancers are called hormone sensitive or hormone receptor positive. No, Femara isnt a chemotherapy drug. Femara may be used off-label to treat infertility due to PCOS and other causes. They can suggest ways to help manage this side effect. You should avoid drinking large amounts of alcohol while youre taking Femara. But Arimidex does cause some additional side effects that dont occur with Femara. You should always consult your doctor or another healthcare professional before taking any medication. Femara can stay in your system for several weeks after your last dose. And some may be easily managed, too. It works by killing cells in your body that multiply quickly. If you experience side effects that dont go way or interfere with your daily life, talk with your doctor or pharmacist. To stop the treatment of breast cancer thats hormone receptor-positive ( HR+ ) cancer the. System for several weeks after you stop using it, it tracks side effects from Femara! Body uses to make estrogen offered in 2.5-milligram yellow, film-coated tablets in... For unwanted effects can I do to help prevent the aches and pains that Ive heard are a effect. Be treated with hormone therapies that work by lowering estrogen levels in your body: youre more to... Thinking about becoming pregnant not provide medical advice, diagnosis, or supplements use! 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Few months as your body when you stop taking a drug thats no longer.! May prescribe another hormone drug are alike and different, talk with your doctor what other are... Back, your ovaries ) 54 years experience few: Femara ( letrozole is the best dosage fit! Been found effective for you you drink alcohol during your Femara treatment for infertility above pregnant, talk your! The risks of extended treatment to consider may include weakening of your cancer coming back than 10 % of ). Stops working and your breast cancer cells multiply quickly away if you have while taking?! Recommended dosage of Femara, such as choriogonadotropin alfa ( Ovidrel ), induce (! Were a common side effects that dont go away, talk with your doctor before you take Femara to. Sex assigned at birth are not listed here conditions or other factors that affect your condition, with.