Treatment with proton pump inhibitors may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter (see section 5.1). Sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing (severe allergic reaction). Yellow skin, dark urine and tiredness which can be symptoms of liver problems. Your doctor should monitor certain health issues. Esomeprazole magnesium may be used as part of a combination therapy. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. Uses of Espoan Espoan is a medicine used to treat ulcers of the stomach, duodenum, esophagitis as well as other symptoms of the gastrointestinal tract. Esomeprazole inhibits CYP2C19, the major esomeprazole-metabolising enzyme. Be sure to avoid doing this when the weather is very hot or very cold. Feeling sick (nausea) or being sick (vomiting). Almost 80% of an oral dose of esomeprazole is excreted as metabolites in the urine, the remainder in the faeces. Inconsistent data on the clinical implications of this PK/PD interaction in terms of major cardiovascular events have been reported from observational and clinical studies. At the end of 120 minutes, drain the acid solution slowly without losing any tablet fragments.Transfer the entire content to a 100ml volumetric flask (in the case of 20mg tablets) or a 200ml volumetric flask (in case of 40mg tablets), add about 80ml of . See your doctor. If you get any of these symptoms, please tell your doctor promptly. Contraindications of Aspirin 75 MG If you are allergic to acetylsalicylic acid or any of the ingredients of the Aspirin tablet. Healing of gastric ulcers associated with NSAID therapy. As a mother of 3 little kids and working. The clinical importance and the mechanisms behind these reported interactions are not always known. Esomeprazole gastro-resistant tablets are not recommended for children less than 12 years old. Joint pains (arthralgia) or muscle pains (myalgia). Interaction studies have only been performed in adults. Tablet core: Hydroxypropyl cellulose (E463), Crospovidone (Type A), Tablet coating: Povidone (K30), Macrogol-400, Macrogol-4000, Macrogol 6000, Hypromellose phthalate (HP-55S), Hypromellose phthalate (HP-50), Diethylphthalate, Hydroxypropyl cellulose, Microcrystaline cellulose (PH 101), Microcrystaline cellulose (PH 112), Crosspovidone (TypeB), Sodium stearyl fumarate, Opadry 03B86651 Brown (HMPC 2910/Hypromellose 6cP, Titanium Dioxide(E171), Macrogol/PEG 400, Iron Oxide red (E172)), Sugar spheres (sucrose and maize starch), Talc (E553b), Esomeprazole 20 mg gastro-resistant tablets are light brick red to brown coloured, oval, biconvex, film-coated tablets with E5 debossed on one side and plain on other side, Esomeprazole 40 mg gastro-resistant tablets are light brick red to brown coloured, oval, biconvex, film-coated tablets with E6 debossed on one side and plain on other side, Product is available in following pack sizes. Digoxin toxicity has been rarely reported. Your doctor will adjust the dose depending on your needs and will also decide how long you need to take the medicine for. Therefore, a maximum of 20 mg should not be exceeded in patients with severe dysfunction. Symptoms can include: Vitamin B-12 deficiency. The treatment duration is 4-8 weeks. Your doctor will also tell you to take antibiotics for example amoxicillin and clarithromycin. For patients with severe liver impairment, a maximum dose of 20 mg esomeprazole should not be exceeded (see section 5.2). Esomeprazole 20 mg Gastro-resistant Tablets - Summary of Product Characteristics (SmPC) - (emc) Esomeprazole 20 mg Gastro-resistant Tablets Active Ingredient: esomeprazole magnesium dihydrate Company: Cipla EU Ltd See contact details ATC code: A02BC05 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) Take this drug at least one hour before meals. Esomeprazole may cause serious side effects. Hypersensitivity to the active substance, to substituted benzimidazoles or to any of the excipients listed in section 6.1. The recommended dose is one Esomeprazole 20 mg tablet once a day. However, you dont need to change your diet. Heartburn can mimic early symptoms of a heart attack. The plasma elimination half-life is about 1.3 hours after repeated once daily dosing. Its oral formulation requires therapeutic drug monitoring. 2021 [Cited 3 December 2021]. What Esomeprazole is and what it is used for, 2. significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melaena) and when gastric ulcer is suspected or present, malignancy should be excluded, as treatment with esomeprazole may alleviate symptoms and delay diagnosis. Esomeprazole 20 mg gastro-resistant tablets: Pink coloured, capsule shaped, biconvex, film coated tablets debossed '20' on one side and plain on other side. There are other drugs available to treat your condition. Immediately inject 5-10 ml into the tube. To treat heartburn caused by gastroesophageal reflux disease (GERD). Rinse the glass with half a glass of water and drink. Do not use this medicine after the expiry date which is stated on the blister and the carton after [Exp]. sachet (ask your doctor or pharmacist if you require further information). This information is for use by healthcare professionals, Dixcart House, Addlestone Road, Bourne Business Park, Addlestone,, KT15 2LE, UK. Dose adjustment is not required in the elderly. If you notice any of the following serious side effects, stop taking Esomeprazole and contact a doctor immediately: These effects are rare and may affect up to 1 in 1,000 people. The occurrence of rebleeding within 3 days was 5.9% in the esomeprazole treated group compared to 10.3% for the placebo group. 2. To help avoid interactions, your doctor should manage all of your medications carefully. The recommended dose is Esomeprazole 40 mg twice a day. If symptom control has not been achieved after 4 weeks, the patient should be further investigated. If you cannot swallow at all, the tablet can be mixed with some water and put into a syringe. It allows continued monitoring of the benefit/risk balance of the medicinal product. If you have trouble swallowing the tablets: Put them into a glass of still (non-fizzy) water. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. This information is not a substitute for medical advice. If you are due to have a specific blood test (Chromogranin A). Ranbaxy (UK) Limited a Sun Pharmaceutical Company. The remaining part is dependent on another specific isoform, CYP3A4, responsible for the formation of esomeprazole sulphone, the main metabolite in plasma. 4. If you are on esomeprazole for more than three months it is possible that the levels of magnesium in your blood may fall. Esomeprazole sodium comes in an intravenous (IV) form, which is only given by a healthcare provider. They work by reducing the amount of acid that your stomach produces. Uses Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). 20 mg or 40 mg taken once per day for up to 6 months. For children: Esomeprazole magnesium hasnt been studied in children younger than one month. Symptoms can include: Fundic gland polyps (These dont usually cause symptoms.). Food intake both delays and decreases the absorption of esomeprazole although this has no significant influence on the effect of esomeprazole on intragastric acidity. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes. The major part of the metabolism of esomeprazole is dependent on the polymorphic CYP2C19, responsible for the formation of the hydroxy- and desmethyl metabolites of esomeprazole. The recommended initial dosage is esomeprazole 40 mg twice daily. Not all pack sizes may be marketed. Healthcare professionals are asked to report any suspected adverse reactions Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. fever, angioedema and anaphylactic reaction/shock. If youre taking this drug to prevent ulcers, your doctor will do tests to check if its working for you. Call your doctor right away if you have serious side effects. Your doctor will check to make sure your new drug will work with esomeprazole magnesium. After repeated administration with 20 mg esomeprazole once daily for five days, mean peak acid output after pentagastrin stimulation is decreased 90% when measured 6-7 hours after dosing on day five. Sucrose: Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine. All rights reserved. Symptoms can include: If you develop these symptoms, call 911 or go to the nearest emergency room. Swallow the mixture right away. For patients who cannot swallow, the tablets can be dispersed in non-carbonated water and administered through a gastric tube. Esomeprazole should not be used concomitantly with nelfinavir (see section 4.5). Buy Esomeprazole 40mg Heartburn Relief, 28 Capsules for 19.99 Shop By Category NHS Prescriptions Pet Meds Contact Us Blogs Guides About Us All Guides Erectile Dysfunction Weight Loss Hair Loss Stop Smoking This medicine can affect the results of certain medical tests. If you have severe liver disease, your body may not be able to process this drug as well. An interaction is when a substance changes the way a drug works. Children who weigh less than 44 lb (20 kg): Given 10 mg once per day for 8 weeks. This can further decrease your low vitamin B-12 levels. Effects of other medicinal products on the pharmacokinetics of esomeprazole, Medicinal products which inhibit CYP2C19 and/or CYP3A4. If you get any side effects, talk to your doctor or pharmacist. Frequent Heartburn? Symptoms of an overdose of this drug can include: If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. The recommended dose is one Esomeprazole 20 mg gastro-resistant tablet twice a day for one week. Each gastro-resistant tablet contain 20 mg esomeprazole (as magnesium dihydrate). However, side effects such as dizziness and blurred vision may uncommonly or rarely occur (see section 4). This medication is used to treat disulfiram-alcohol-fasting stomach acid reducers, including a disulfiram-alcohol-free day. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. It is also found in an antibiotic used to treat conditions such as heartburn, gerd or more commonly known as proper gastrointestinal conditions. Sometimes doses up to 240 mg per day are needed. Esomeprazole 20 mg gastro-resistant tablets. In healthy volunteers, concomitant administration of 40 mg esomeprazole resulted in a 32% increase in area under the plasma concentration-time curve (AUC) and a 31% prolongation of elimination half-life (t1/2) but no significant increase in peak plasma levels of cisapride. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. Combination with two antibiotics: esomeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg are all administered together twice daily for one week. Ketoconazole, itraconazole or voriconazole (used to treat infections caused by a fungus). When suggestions are available use up and down arrows to review and ENTER to select. Let your doctor know if you start taking any other drug. Adverse reactions such as dizziness (uncommon) and blurred vision (rare) has been reported (see section 4.8). Talk with your doctor about this risk. This includes any possible side effects not listed in this leaflet. Esomeprazole is acid labile and is administered orally as gastro-resistant granules. DOMPERIDONE+ESOMEPRAZOLE is used to treat acidity, heartburn, gastro-oesophageal reflux disease (GER. 1. Carcinogenicity studies in the rat with the racemic mixture have shown gastric ECL-cell hyperplasia and carcinoids. Heartburn is a burning feeling in your chest and throat. The solid pieces contain the medicine - do not chew or crush them. 20mg: Each tablet contains 20 mg esomeprazole (as esomeprazole magnesium amorphous). The symptoms described in connection with 280 mg were gastrointestinal symptoms and weakness. 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