Abstract Source: Cancer Prev Res (Phila Pa). The administration of Ellagic acid, Kaempferol, and Quercetin as combined drug via the novel drug delivery systems will be a valuable therapeutic choice for the . Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) ++ transcript in estrogen receptor-positive MCF-7 breast cancer cells Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. It also helps to reduce inflammation and may even be effective at fighting against prostate cancer. Ellagic acid estrogen Prevention of oxidative DNA damage by bioactive berry components. 1 Punicalagin/urolithin blocks the conversion of testosterone to estrogen. It affects the testicular function and leads to sterility. To determine whether dietary berries and ellagic acid prevent 17beta-estradiol (E(2))-induced mammary tumors by altering estrogen metabolism, we . Clin Biochem 2009;42:1358-62. PubMed journal article: Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. . . Third, ellagic acid causes G-arrest. Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. It is the dilactone of hexahydroxydiphenic acid. 20, pp. Estrogen stimulates the proliferation of breast cancer cells and the growth of estrogen-responsive tumors. Ellagic Acid is a naturally occurring phenolic constituent in certain fruits and nuts. Ellagic acid also suppresses the expression of cyclooxygenase 2 and inducible nitric oxide synthase via the inhibition of nuclear factor-kappa B (NF-B) activity in several normal and cancer cells (8,9). Ellagic acid hydrate | C14H8O9 | CID 16212384 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev. The induction of mammary tumors in ACI rats by estrogen mimics the human scenario more closely than tumors induced by environmental carcinogens. Ellagic acid can reduce the activity of tyrosinase and catalase, thereby inhibiting the formation of melasma. Estrogen overload can be problematic for a number of reasons. Punica granatum (P. granatum) is a fruit-bearing tree from the Punicaceae family, indigenous to Iran. Design and methods. Studies show the antioxidant can help fight against free radicals and toxins. This makes them have a cardioprotective effect on humans. GreenMedInfo Summary. To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor . Ellagic acid is a naturally occurring compound called a tannin, found in red raspberries, strawberries, pomegranates, and walnuts. Ellagic acid is an antioxidant found naturally in many of your favorite foods, including many fruits and vegetables. Some foods also contain a compound called ellagitannin, which your body . These observations provide mechanistic insights into the new molecular events behind the chemoprevention action of ellagic acid in and treatment of breast cancer. Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. Phytoestrogens. These include ellagic acid, punicic acid, phenols, and flavonoids. A type of sugar; the chief source of energy . Ellagic acid also reportedly can help the liver break down or remove cancer-causing agents from the blood. Awards 0. Its healing quality is due to the phytochemicals present in the plant. By using our site, you agree to our collection of information through the use of . Research in the past decade confirms that ellagic acid markedly inhibits the ability of other chemicals to cause mutations in bacteria. Flavonoids. It is revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. In this study, we investigated efficacy of dietary berries and ellagic acid to reduce estrogen-mediated mammary tumorigenesis. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. Three time points - early (6 weeks), intermediate (18 weeks) and late (24 weeks) were . 2008;60(2):227-34. Three time pointsearly (6 wk), intermediate (18 wk), and late (24 wk)were chosen, and the . blueberries) are a rich source of polyphenolic compounds, including ellagic acid. This results in less testosterone being converted to DHT, thereby . To determine whether berries and ellagic acid affect estrogen metabolism, we examined the regulation of gene expression of key enzymes involved in estrogen metabolism and signaling in the mammary tissue during the course of mammary tumorigenesis. alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Showing the single result . of Estrogen Metabolism Harini S. Aiyer1 and Ramesh C. Gupta1,2 Abstract To determine whether dietary berries and ellagic acid prevent 17-estradiol (E 2)-induced mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen Irish rats (n = 6 per group) into five groups: sham implant + control diet, E 2 implant + control . Research on ellagic acid's effect on cancer first appeared in the 1970s and . Beefsteak Fungus. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Nutr Cancer. The concentration of the acid is relatively low in most foods. In addition, research has found that it has antibacterial and antiviral properties. The present study aimed to evaluate the effects of ellagic acid on testicular tissue changes, sexual hormones, antioxidant defense system, and caspase-9 and Bcl2 gene expression in the busulfan-induced relative sterile rat model. . Kakadu Plum Organic 10:1 EXTRACT Powder $ 14.99 - $ 41.99 (inc GST) 0021-8561 Subject: mineralization, pomegranates, humans, hormone receptors, ellagic acid, osteoblasts, estrogenic properties, cell lines, breast neoplasms Ellagic acid seems to have some particular anti-cancer properties. Ellagic acid is a powerful antioxidant in many foods. In other laboratory studies, ellagic acid seems to reduce the effect of estrogen hormone in women in promoting growth of . Aromatase plays a key role in breast carcinogenesis; therefore, the growth of breast cancer is . Contains aboundant nutrients frim pomegranate (vitamin B C, ellagic acid, estrogen, polyphenol, anthocyanin, citric acid, folic acid, calcium, potassium, zinc, etc.). 120. Ellagic acid was selected based on >95% inhibition of 8-oxodeoxyguosine (8-oxodG) and other unidentified oxidative DNA adducts induced by 4-hydroxy-17-estradiol and CuCl2 in vitro. PDF | To determine whether dietary berries and ellagic acid prevent 17-estradiol (E2)-induced mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen Irish rats ( n = 6 per group) into five groups: sham implant + control diet, E2 implant + control diet (E2-CD), E2 + 2.5% black raspberry (E2-BRB), E2 + 2.5% blueberry (E2-BB), and E2 + 400 ppm ellagic acid (E2-EA). These are called phytonutrients or phytochemicals."Phyto" refers to the . Ellagic acid is a naturally selective estrogen receptor- and estrogen receptor- ligand, exhibiting selective estrogen receptor modulator properties similar to those of synthetic natural . Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats Harini S Aiyer, Cidambi Srinivasan, Ramesh C Gupta Nutr Cancer . 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